{"entity":{"id":"dfci-paxman-limb-cryocompression","kind":"trial","name":"Dana-Farber trial of the Paxman limb cryocompression system","aka":["Cryocompression for CIPN"],"tldr":"A US study testing Paxman's machine that cools and squeezes the hands and feet during taxane chemotherapy to prevent nerve damage.","summary":"The Dana-Farber study plans 50 participants and lists taxane-induced peripheral neuropathy as its condition, with the Paxman Limb Cryocompression System as the intervention. ClinicalTrials.gov gives an estimated primary completion in August 2027.","status":"recruiting","asOf":"2026-11-04","links":[{"label":"ClinicalTrials.gov NCT07064798","url":"https://clinicaltrials.gov/study/NCT07064798"},{"label":"Paxman: the Paxman Neuropathy System (limb cryocompression)","url":"https://paxmangroup.com/reduce-nerve-damage/paxman-neuropathy/"}],"tags":["machines-wave3"],"related":[],"cancers":[],"sections":[],"technologies":["limb-cryocompression-devices"],"targets":[],"drugs":["paclitaxel","docetaxel"],"companies":["paxman"],"institutions":["dana-farber"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo machines inventory (openFDA, accessdata.fda.gov, ClinicalTrials.gov v2, Europe PMC, maker pages)","editedOn":"2026-11-04"},"nct":"NCT07064798","phase":"not-applicable","setting":"Patients receiving taxane chemotherapy, using the Paxman Limb Cryocompression System to prevent peripheral neuropathy","sponsor":"Dana-Farber Cancer Institute","started":"2025-10-22","startedType":"actual","enrolled":50,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/dfci-paxman-limb-cryocompression/","neighbours":{"technology":[{"id":"limb-cryocompression-devices","kind":"technology","name":"Limb cryocompression devices for chemotherapy nerve damage (Paxman Neuropathy System, Hilotherm ChemoCare)","route":"/technologies/limb-cryocompression-devices/"}],"drug":[{"id":"docetaxel","kind":"drug","name":"Docetaxel","route":"/drugs/docetaxel/"},{"id":"paclitaxel","kind":"drug","name":"Paclitaxel / nab-paclitaxel","route":"/drugs/paclitaxel/"}],"company":[{"id":"paxman","kind":"company","name":"Paxman","route":"/companies/paxman/"}],"institution":[{"id":"dana-farber","kind":"institution","name":"Dana-Farber Brigham Cancer Center","route":"/institutions/dana-farber/"}]}}