{"entity":{"id":"dfp-14927","kind":"drug","name":"DFP-14927","aka":[],"tldr":"DFP-14927 is an experimental PEGylated polymer conjugate of the nucleoside analogue DFP-10917 from Delta-Fly Pharma, in phase 1 trials for advanced solid tumours.","summary":"DFP-14927 is a PEGylated polymer conjugate of the nucleoside analogue DFP-10917 from Delta-Fly Pharma. A large four-arm PEGylated form of DFP-10917 designed for once-weekly dosing. Its furthest stage is phase 1, for advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Phase 1 NCT03943004 in advanced solid tumours, registry status RECRUITING. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Delta-Fly Pharma: delta-flypharma.co.jp","url":"https://www.delta-flypharma.co.jp/en/r-and-d"},{"label":"Delta-Fly Pharma: clinicaltrials.gov","url":"https://clinicaltrials.gov/study/NCT03943004"},{"label":"ClinicalTrials.gov: trials of DFP-14927","url":"https://clinicaltrials.gov/search?intr=DFP-14927"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["delta-fly-pharma"],"institutions":[],"pathways":[],"terms":[],"trials":["nct03943004"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"DFP-14927","modality":"PEGylated polymer conjugate of the nucleoside analogue DFP-10917","mechanism":"A large four-arm PEGylated form of DFP-10917 designed for once-weekly dosing.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/dfp-14927/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"delta-fly-pharma","kind":"company","name":"Delta-Fly Pharma","route":"/companies/delta-fly-pharma/"}],"trial":[{"id":"nct03943004","kind":"trial","name":"Trial of DFP-14927 in Advanced Solid Tumors","route":"/trials/nct03943004/"}]}}