{"entity":{"id":"dgcr8","kind":"target","name":"DGCR8","aka":["DGCR8 microprocessor complex subunit","Microprocessor complex subunit DGCR8","DGCRK6","Gy1","pasha","C22orf12"],"tldr":"DGCR8 (Microprocessor complex subunit DGCR8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Thyroid cancer, Diffuse large B-cell lymphoma and 3 more.","summary":"Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs.\n\nIntOGen calls it a driver in 4 cohorts (3 activating, 1 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS, Pleural Mesothelioma, Well-Differentiated Thyroid Cancer, Wilms' Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2847","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2847"},{"label":"UniProt Q8WYQ5","url":"https://www.uniprot.org/uniprotkb/Q8WYQ5/entry"},{"label":"NCBI Gene 54487","url":"https://www.ncbi.nlm.nih.gov/gene/54487"},{"label":"Ensembl ENSG00000128191","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128191"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["mesothelioma","thyroid","dlbcl","pleural-mesothelioma","papillary-thyroid-cancer","wilms-tumor"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DGCR8","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:2847","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2847","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WYQ5","url":"https://www.uniprot.org/uniprotkb/Q8WYQ5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen DGCR8","url":"https://www.intogen.org/search?gene=DGCR8","note":"driver in 4 cohorts (Act 3, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2847","ensembl":"ENSG00000128191","uniprot":"Q8WYQ5","entrez":"54487","biology":"Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognises and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing. Location: Nucleus; Nucleus, nucleolus (UniProt). Locus 22q11.21 (HGNC).","whereFound":["Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Thyroid cancer: IntOGen driver in 1 cohort (WDTC)","Diffuse large B-cell lymphoma: IntOGen driver in 1 cohort (DLBCLNOS)","Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Papillary thyroid cancer: IntOGen driver in 1 cohort (WDTC)","Wilms tumour: IntOGen driver in 1 cohort (WT)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/dgcr8/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"papillary-thyroid-cancer","kind":"cancer","name":"Papillary thyroid cancer","route":"/cancers/papillary-thyroid-cancer/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"},{"id":"wilms-tumor","kind":"cancer","name":"Wilms tumour (nephroblastoma)","route":"/cancers/wilms-tumor/"}]}}