{"entity":{"id":"diatrizoate","kind":"drug","name":"Diatrizoate meglumine and diatrizoate sodium (oral contrast)","aka":["diatrizoate","Gastrografin","amidotrizoate","diatrizoic acid"],"tldr":"A drink of iodine-based dye used to outline the gut on X-rays and CT scans, especially when a leak or perforation is possible and barium would be unsafe.","summary":"Bracco's Gastrografin (NDA 011245, first approved 17 January 1958) \"is indicated for radiographic examination of segments of the gastrointestinal tract (esophagus, stomach, proximal small intestine, and colon)\" and \"is particularly indicated when a more viscous agent such as barium sulfate, which is not water-soluble, is not feasible or is potentially dangerous\". It may also be used as an adjunct for CT of the torso to distinguish bowel loops.","status":"approved","asOf":"2026-11-04","links":[{"label":"Drugs@FDA Gastrografin (NDA 011245)","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=011245"},{"label":"DailyMed label: Gastrografin","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8c2340e4-2b42-45dc-8fac-9960e8172547"}],"tags":["contrast-agents-gaps-2026-11","diagnostic"],"related":[],"cancers":[],"sections":[],"technologies":["iodinated-contrast-media","ct"],"targets":[],"drugs":[],"companies":["bracco"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo contrast agent gap fill (Drugs@FDA, FDA labels, DailyMed, EMA register, WHO ATC index)","editedOn":"2026-11-04"},"brand":"Gastrografin","modality":"Water-soluble iodinated contrast agent for X-ray and CT of the bowel (oral or rectal)","mechanism":"An ionic iodinated molecule that fills the bowel and absorbs X-rays, outlining the gut; being water-soluble, it is safer than barium where a leak is possible.","approvals":[{"region":"US","year":1958,"indication":"Radiographic examination of the gastrointestinal tract; adjunct to CT of the torso","note":"NDA 011245; Bracco"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/diatrizoate/","neighbours":{"technology":[{"id":"ct","kind":"technology","name":"CT (computed tomography)","route":"/technologies/ct/"},{"id":"iodinated-contrast-media","kind":"technology","name":"Iodinated and barium contrast for CT and X-ray","route":"/technologies/iodinated-contrast-media/"}],"company":[{"id":"bracco","kind":"company","name":"Bracco (Bracco Imaging and Bracco Diagnostics)","route":"/companies/bracco/"}]}}