{"entity":{"id":"diffusion-pharmaceuticals","kind":"company","name":"Diffusion Pharmaceuticals","aka":["Diffusion Pharmaceuticals Inc","Diffusion Pharmaceuticals LLC"],"tldr":"Diffusion developed trans sodium crocetinate, a small molecule meant to carry more oxygen into tumours so radiotherapy works better; its phase 3 trial in glioblastoma was cut short and the company merged into another biotech in 2023.","summary":"Diffusion Pharmaceuticals, founded in 2001 in Charlottesville, Virginia, developed trans sodium crocetinate (TSC), a carotenoid derivative that increases oxygen diffusion into hypoxic tissue, as a radiosensitiser. Its phase 3 INTACT trial in newly diagnosed glioblastoma was terminated early, and the company merged with EIP Pharma in 2023. Its trials remain on ClinicalTrials.gov under Diffusion as lead sponsor.","asOf":"2026-09-11","links":[{"label":"Official website","url":"http://www.diffusionpharma.com"},{"label":"ClinicalTrials.gov: trials led by Diffusion Pharmaceuticals Inc","url":"https://clinicaltrials.gov/search?lead=Diffusion%20Pharmaceuticals%20Inc"},{"label":"Wikidata","url":"https://www.wikidata.org/wiki/Q5275432"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["glioblastoma"],"sections":["radiation"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["pivotal-trial","clinical-trial"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Charlottesville, VA","country":"US","companyType":"biotech","website":"http://www.diffusionpharma.com","founded":2001,"stage":"acquired","investors":[],"funding":[]},"route":"/companies/diffusion-pharmaceuticals/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"section":[{"id":"radiation","kind":"section","name":"Radiation Therapy","route":"/fronts/radiation/"}],"term":[{"id":"clinical-trial","kind":"term","name":"Clinical trial","route":"/terms/clinical-trial/"},{"id":"pivotal-trial","kind":"term","name":"Pivotal (registrational) trial","route":"/terms/pivotal-trial/"}]}}