{"entity":{"id":"disc-3405","kind":"drug","name":"DISC-3405","aka":["MWTX-003"],"tldr":"DISC-3405 is an experimental monoclonal antibody from Disc Medicine, in phase 2 trials for polycythaemia vera.","summary":"DISC-3405 (MWTX-003) is a monoclonal antibody from Disc Medicine, with Mabwell as licensor (formerly MWTX-003). An antibody against TMPRSS6 that induces hepcidin and so restricts iron for red-cell production, tested to control red-cell overproduction in polycythaemia vera. Its furthest stage is phase 2, for polycythaemia vera. ClinicalTrials.gov registers it in one study linked below. Phase 2 in PV (NCT06985147) active, not recruiting. Whether it works in people has not been established unless a trial below reports it.","status":"phase-2","asOf":"2026-11-03","links":[{"label":"Disc Medicine: discmedicine.com","url":"https://www.discmedicine.com/pipeline"},{"label":"Disc Medicine: discmedicine.com","url":"https://www.discmedicine.com/pipeline"},{"label":"ClinicalTrials.gov: trials of DISC-3405","url":"https://clinicaltrials.gov/search?intr=DISC-3405"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["myeloproliferative-neoplasms"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["disc-medicine"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06985147"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"DISC-3405","modality":"Monoclonal antibody","mechanism":"An antibody against TMPRSS6 that induces hepcidin and so restricts iron for red-cell production, tested to control red-cell overproduction in polycythaemia vera.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/disc-3405/","neighbours":{"cancer":[{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"}],"company":[{"id":"disc-medicine","kind":"company","name":"Disc Medicine","route":"/companies/disc-medicine/"}],"trial":[{"id":"nct06985147","kind":"trial","name":"A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)","route":"/trials/nct06985147/"}]}}