{"entity":{"id":"discover-galleri-symptomatic","kind":"trial","name":"DISCOVER (Galleri over time in people with symptoms)","aka":["DISCOVER study","DISCOVERY"],"tldr":"A small Dana-Farber study of what the Galleri test finds, and misses, when it is used repeatedly in people who have symptoms.","summary":"DISCOVER (NCT07390643) is a single-arm interventional study sponsored by Dana-Farber Cancer Institute. Its primary outcomes are the type, incidence and stage of cancers found by Galleri and of cancers it did not detect.\n\nThe registry record, read on 29 October 2026, gives its status as not yet recruiting, with an estimated 100 participants, a planned start in July 2026 and primary completion expected on 31 January 2027.","status":"planned","asOf":"2026-10-29","links":[{"label":"ClinicalTrials.gov NCT07390643","url":"https://clinicaltrials.gov/study/NCT07390643"}],"tags":[],"related":[],"cancers":[],"sections":["early-detection"],"technologies":["mced","liquid-biopsy"],"targets":[],"drugs":["galleri"],"companies":["grail"],"institutions":["dana-farber"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07390643","phase":"not-applicable","setting":"People with symptoms that could be cancer at Dana-Farber Cancer Institute, tested with Galleri over time","sponsor":"Dana-Farber Cancer Institute","started":"2026-07","startedType":"estimated","enrolled":100,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/discover-galleri-symptomatic/","neighbours":{"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"}],"technology":[{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"},{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"}],"drug":[{"id":"galleri","kind":"drug","name":"Galleri","route":"/drugs/galleri/"}],"company":[{"id":"grail","kind":"company","name":"GRAIL","route":"/companies/grail/"}],"institution":[{"id":"dana-farber","kind":"institution","name":"Dana-Farber Brigham Cancer Center","route":"/institutions/dana-farber/"}]}}