{"entity":{"id":"dkk1","kind":"target","name":"DKK1","aka":["dickkopf Wnt signaling pathway inhibitor 1","Dickkopf-related protein 1","DKK-1"],"tldr":"DKK1 (Dickkopf-related protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"Antagonises canonical Wnt signalling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalisation of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Irinotecan, Levoleucovorin, Oxaliplatin and Fluorouracil.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2891","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2891"},{"label":"UniProt O94907","url":"https://www.uniprot.org/uniprotkb/O94907/entry"},{"label":"NCBI Gene 22943","url":"https://www.ncbi.nlm.nih.gov/gene/22943"},{"label":"Ensembl ENSG00000107984","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107984"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DKK1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:2891","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2891","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O94907","url":"https://www.uniprot.org/uniprotkb/O94907/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene DKK1","url":"https://civicdb.org/features/9171","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:2891","ensembl":"ENSG00000107984","uniprot":"O94907","entrez":"22943","biology":"Antagonises canonical Wnt signalling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalisation of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Location: Secreted (UniProt). Locus 10q21.1 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/dkk1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}