{"entity":{"id":"dll1","kind":"target","name":"DLL1","aka":["delta like canonical Notch ligand 1","Delta-like protein 1"],"tldr":"DLL1 (Delta-like protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner. Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signalling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signalling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes affected pathway 0.79, literature 0.94, genetic association 0.18, somatic mutation 0.23, animal model 0.54).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2908","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2908"},{"label":"UniProt O00548","url":"https://www.uniprot.org/uniprotkb/O00548/entry"},{"label":"NCBI Gene 28514","url":"https://www.ncbi.nlm.nih.gov/gene/28514"},{"label":"Ensembl ENSG00000198719","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198719"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DLL1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2908","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2908","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O00548","url":"https://www.uniprot.org/uniprotkb/O00548/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198719","url":"https://platform.opentargets.org/target/ENSG00000198719/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"hgnc":"HGNC:2908","ensembl":"ENSG00000198719","uniprot":"O00548","entrez":"28514","biology":"Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner. Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signalling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signalling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation. Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signalling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signalling pathway. Location: Apical cell membrane; Cell junction, adherens junction; Membrane raft (UniProt). Locus 6q27 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/dll1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}