{"entity":{"id":"dlst","kind":"target","name":"DLST","aka":["dihydrolipoamide S-succinyltransferase","Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial","OGDC-E2","KGD2"],"tldr":"DLST (Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.","summary":"Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion.\n\n","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2911","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2911"},{"label":"UniProt P36957","url":"https://www.uniprot.org/uniprotkb/P36957/entry"},{"label":"NCBI Gene 1743","url":"https://www.ncbi.nlm.nih.gov/gene/1743"},{"label":"Ensembl ENSG00000119689","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119689"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DLST","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2911","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2911","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P36957","url":"https://www.uniprot.org/uniprotkb/P36957/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000119689","url":"https://platform.opentargets.org/target/ENSG00000119689/associations","note":"per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.66 (GraphQL API, CC0)"}],"hgnc":"HGNC:2911","ensembl":"ENSG00000119689","uniprot":"P36957","entrez":"1743","biology":"Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localises in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. Location: Mitochondrion matrix; Nucleus (UniProt). Locus 14q24.3 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.66 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/dlst/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}