{"entity":{"id":"dna2","kind":"target","name":"DNA2","aka":["DNA replication helicase/nuclease 2","DNA replication ATP-dependent helicase/nuclease DNA2","KIAA0083","DNA2L"],"tldr":"DNA2 (DNA replication ATP-dependent helicase/nuclease DNA2) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.","summary":"Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.87, genetic association 0.03).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2939","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2939"},{"label":"UniProt P51530","url":"https://www.uniprot.org/uniprotkb/P51530/entry"},{"label":"NCBI Gene 1763","url":"https://www.ncbi.nlm.nih.gov/gene/1763"},{"label":"Ensembl ENSG00000138346","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138346"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DNA2","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2939","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2939","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P51530","url":"https://www.uniprot.org/uniprotkb/P51530/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000138346","url":"https://platform.opentargets.org/target/ENSG00000138346/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:2939","ensembl":"ENSG00000138346","uniprot":"P51530","entrez":"1763","biology":"Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. Location: Nucleus; Mitochondrion (UniProt). Locus 10q21.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/dna2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}