{"entity":{"id":"dnajb1","kind":"target","name":"DNAJB1","aka":["DnaJ heat shock protein family (Hsp40) member B1","DnaJ homolog subfamily B member 1","Hsp40","Sis1","RSPH16B","HSPF1"],"tldr":"DNAJB1 (DnaJ homolog subfamily B member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region. Stimulates the association between HSC70 and HIP.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.00, somatic mutation 0.90).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5270","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5270"},{"label":"UniProt P25685","url":"https://www.uniprot.org/uniprotkb/P25685/entry"},{"label":"NCBI Gene 3337","url":"https://www.ncbi.nlm.nih.gov/gene/3337"},{"label":"Ensembl ENSG00000132002","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132002"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DNAJB1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5270","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5270","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P25685","url":"https://www.uniprot.org/uniprotkb/P25685/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000132002","url":"https://platform.opentargets.org/target/ENSG00000132002/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:5270","ensembl":"ENSG00000132002","uniprot":"P25685","entrez":"3337","biology":"Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Location: Cytoplasm; Nucleus; Nucleus, nucleolus (UniProt). Locus 19p13.12 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/dnajb1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}