{"entity":{"id":"dnajc1","kind":"target","name":"DNAJC1","aka":["DnaJ heat shock protein family (Hsp40) member C1","DnaJ homolog subfamily C member 1","DNAJL1","ERdj1","MTJ1"],"tldr":"DNAJC1 (DnaJ homolog subfamily C member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"May modulate protein synthesis.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.71, genetic association 0.65).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20090","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20090"},{"label":"UniProt Q96KC8","url":"https://www.uniprot.org/uniprotkb/Q96KC8/entry"},{"label":"NCBI Gene 64215","url":"https://www.ncbi.nlm.nih.gov/gene/64215"},{"label":"Ensembl ENSG00000136770","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136770"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DNAJC1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:20090","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20090","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96KC8","url":"https://www.uniprot.org/uniprotkb/Q96KC8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000136770","url":"https://platform.opentargets.org/target/ENSG00000136770/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:20090","ensembl":"ENSG00000136770","uniprot":"Q96KC8","entrez":"64215","biology":"May modulate protein synthesis. Location: Endoplasmic reticulum membrane; Nucleus membrane; Microsome membrane (UniProt). Locus 10p12.31 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/dnajc1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}