{"entity":{"id":"dnajc12","kind":"target","name":"DNAJC12","aka":["DnaJ heat shock protein family (Hsp40) member C12","JDP1"],"tldr":"DNAJC12 is a co-chaperone gene that is strongly expressed in oestrogen receptor-positive (luminal) breast cancers and is used as a luminal marker.","summary":"UniProt describes DNAJC12 as an Hsp40 co-chaperone that helps fold the aromatic amino acid hydroxylases. In breast cancer it is an oestrogen-responsive gene that separates luminal from basal-like tumours in expression data, and one of the genes whose protein closely follows its transcript.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:28908","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28908"},{"label":"UniProt Q9UKB3","url":"https://www.uniprot.org/uniprotkb/Q9UKB3/entry"}],"tags":["cansim-terms"],"related":[],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["co-amplification","cancer-ai-vocabulary","pam50","hormone-receptor-status","mrna-protein-concordance"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme."],"provenance":{"editedBy":"OnCo CanSim terms wave (HGNC REST, UniProt REST)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"symbol":"DNAJC12","role":["biomarker"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:28908","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28908","note":"approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)"},{"label":"UniProt Q9UKB3","url":"https://www.uniprot.org/uniprotkb/Q9UKB3/entry","note":"protein name, function and tissue specificity text (REST API, 2026-09-24)"}],"specificitySources":[],"hgnc":"HGNC:28908","ensembl":"ENSG00000108176","uniprot":"Q9UKB3","entrez":"56521","biology":"Probable co-chaperone for the folding of biopterin-dependent aromatic amino acid hydroxylases (PAH, TH, TPH1 and TPH2); expressed at high levels in brain, heart and testis (UniProt Q9UKB3).","whereFound":["Locus 10q21.3 (HGNC)."],"targetClass":"other","prevalence":[]},"route":"/targets/dnajc12/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"co-amplification","kind":"term","name":"Co-amplification and the 17q12 HER2 amplicon","route":"/terms/co-amplification/"},{"id":"hormone-receptor-status","kind":"term","name":"Hormone receptor status (ER / PR)","route":"/terms/hormone-receptor-status/"},{"id":"mrna-protein-concordance","kind":"term","name":"mRNA to protein concordance","route":"/terms/mrna-protein-concordance/"},{"id":"pam50","kind":"term","name":"PAM50 / intrinsic subtypes","route":"/terms/pam50/"}]}}