{"entity":{"id":"dnm2","kind":"target","name":"DNM2","aka":["dynamin 2","Dynamin-2","DYNII","DYN2","CMTDIB","CMTDI1","DI-CMTB","CMT2M"],"tldr":"DNM2 (Dynamin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma, Colorectal cancer and 3 more.","summary":"Catalyses the hydrolysis of GTP and utilises this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organisation of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerisation to form a helical polymer around the vesicle membrane and leading to vesicle scission.\n\nOpen Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.54, literature 0.93, genetic association 0.00, somatic mutation 0.98, animal model 0.58).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2974","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2974"},{"label":"UniProt P50570","url":"https://www.uniprot.org/uniprotkb/P50570/entry"},{"label":"NCBI Gene 1785","url":"https://www.ncbi.nlm.nih.gov/gene/1785"},{"label":"Ensembl ENSG00000079805","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000079805"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","non-hodgkin-lymphoma","colorectal","skin-cancer","breast-cancer","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DNM2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2974","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2974","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P50570","url":"https://www.uniprot.org/uniprotkb/P50570/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000079805","url":"https://platform.opentargets.org/target/ENSG00000079805/associations","note":"association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, acute lymphoblastic leukaemia 0.51, non-Hodgkin lymphoma 0.56, skin cancer 0.51, breast cancer 0.51, leukaemia 0.58 (GraphQL API, CC0)"}],"hgnc":"HGNC:2974","ensembl":"ENSG00000079805","uniprot":"P50570","entrez":"1785","biology":"Catalyses the hydrolysis of GTP and utilises this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organisation of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerisation to form a helical polymer around the vesicle membrane and leading to vesicle scission. Plays a role in organisation of the actin cytoskeleton by mediating arrangement of stress fibres and actin bundles in podocytes. During organisation of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers. Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerisation of dynamin spiral polymers, and results in dispersion of actin bundles. Location: Cytoplasm, cytoskeleton; Cytoplasmic vesicle, clathrin-coated vesicle; Cell projection, uropodium; Endosome (UniProt). Locus 19p13.2 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.58 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)","Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)","Acute lymphoblastic leukaemia: Open Targets association 0.51 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/dnm2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}