{"entity":{"id":"dnmt3a","kind":"target","name":"DNA methyltransferase 3A (DNMT3A)","aka":[],"tldr":"DNMT3A writes new methyl marks on DNA; it is one of the most commonly mutated genes in acute myeloid leukaemia and is trapped by the hypomethylating drugs azacitidine and decitabine.","summary":"DNA methyltransferase 3A establishes new (de novo) cytosine methylation. Loss-of-function mutations, most often at R882, are among the commonest events in acute myeloid leukaemia and in age-related clonal haematopoiesis. Azacitidine and decitabine are incorporated into DNA and covalently trap DNA methyltransferases, including DNMT3A, leading to their degradation and to demethylation.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/DNMT3A","links":[{"label":"UniProt Q9Y6K1: DNMT3A","url":"https://www.uniprot.org/uniprotkb/Q9Y6K1/entry"},{"label":"HGNC:2978 DNMT3A","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2978"},{"label":"ChEMBL target CHEMBL1992","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL1992"}],"tags":[],"related":["dnmt1"],"cancers":["aml","mds"],"sections":[],"technologies":[],"targets":[],"drugs":["azacitidine","decitabine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"DNMT3A","biology":"A de novo methyltransferase working with DNMT3L during development and in haematopoietic stem cells; the R882H mutant acts dominantly to reduce methylation.","whereFound":["Haematopoietic stem cells","Mutated in a large share of AML and in clonal haematopoiesis"],"targetClass":"enzyme","prevalence":[{"cancerId":"aml","pct":22.1,"measure":"DNMT3A mutation, exon sequencing of 281 de novo AML cases (62 mutated)","source":"https://doi.org/10.1056/NEJMoa1005143","note":"33.7% in intermediate-risk cytogenetics and absent in favourable-risk disease; R882 the commonest site"}]},"route":"/targets/dnmt3a/","neighbours":{"target":[{"id":"dnmt1","kind":"target","name":"DNMT1 (DNA methyltransferase 1)","route":"/targets/dnmt1/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}],"drug":[{"id":"azacitidine","kind":"drug","name":"Azacitidine","route":"/drugs/azacitidine/"},{"id":"decitabine","kind":"drug","name":"Decitabine","route":"/drugs/decitabine/"}]}}