{"entity":{"id":"dpyd","kind":"target","name":"DPYD","aka":["dihydropyrimidine dehydrogenase","Dihydropyrimidine dehydrogenase [NADP(+)]","DHPDHase"],"tldr":"DPYD (Dihydropyrimidine dehydrogenase [NADP(+)]) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Head and neck squamous cell carcinoma and Gastric & gastro-oesophageal junction cancer.","summary":"Catalyses the reduction of uracil and thymine in the initial step of reductive pyrimidine catabolism, a pathway that yields beta-alanine from uracil and beta-aminoisobutyrate from thymine. Also capable of degrading the chemotherapeutic drug 5-fluorouracil.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 4 variants, naming Fluorouracil, Capecitabine, Tegafur and Leucovorin. Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes clinical 0.94, affected pathway 0.94, literature 0.87, genetic association 0.33, somatic mutation 0.23, animal model 0.38).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3012","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3012"},{"label":"UniProt Q12882","url":"https://www.uniprot.org/uniprotkb/Q12882/entry"},{"label":"NCBI Gene 1806","url":"https://www.ncbi.nlm.nih.gov/gene/1806"},{"label":"Ensembl ENSG00000188641","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000188641"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["head-and-neck","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.94; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DPYD","role":["drug-target","biomarker"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:3012","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3012","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q12882","url":"https://www.uniprot.org/uniprotkb/Q12882/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene DPYD","url":"https://civicdb.org/features/1526","note":"4 evidence items, 0 assertions, 4 variants; diseases: Cancer, Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000188641","url":"https://platform.opentargets.org/target/ENSG00000188641/associations","note":"association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: gastric cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:3012","ensembl":"ENSG00000188641","uniprot":"Q12882","entrez":"1806","biology":"Catalyses the reduction of uracil and thymine in the initial step of reductive pyrimidine catabolism, a pathway that yields beta-alanine from uracil and beta-aminoisobutyrate from thymine. Also capable of degrading the chemotherapeutic drug 5-fluorouracil. Location: Cytoplasm, cytosol (UniProt). Locus 1p21.3 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: CIViC evidence names this disease","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.54 with gastric cancer (MONDO_0001056)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/dpyd/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}]}}