{"entity":{"id":"dsb2455","kind":"drug","name":"DSB2455","aka":[],"tldr":"DSB2455 is an experimental pill being studied to block a DNA-repair enzyme in cancer cells.","summary":"The registry describes DSB2455 as a PARP1-selective inhibitor; the sponsor describes CNS activity. The linked registry records distinguish recruiting, closed, and discontinued studies; those states do not establish comparative efficacy or approval. The sponsor reports FDA Fast Track designation for HRR-altered TNBC brain metastases. Fast Track is a development designation, not marketing approval.","status":"phase-1","asOf":"2026-10-06","links":[{"label":"ClinicalTrials.gov NCT06458712","url":"https://clinicaltrials.gov/study/NCT06458712"},{"label":"Primary publication or sponsor source","url":"https://dukestbio.com/duke-street-bio-fda-fast-track-dsb2455/"}],"tags":[],"related":[],"cancers":["breast-cancer","ovarian","prostate","pancreatic"],"sections":[],"technologies":[],"targets":["parp"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct06458712"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"modality":"Small-molecule PARP1 inhibitor","mechanism":"The registry describes DSB2455 as a PARP1-selective inhibitor; the sponsor describes CNS activity.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/dsb2455/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"target":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"trial":[{"id":"nct06458712","kind":"trial","name":"Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies","route":"/trials/nct06458712/"}]}}