{"entity":{"id":"dsp","kind":"target","name":"DSP","aka":["desmoplakin","Desmoplakin","KPPS2","PPKS2"],"tldr":"DSP (Desmoplakin) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Nasopharyngeal carcinoma.","summary":"A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Critical for cell-cell adhesion in early stage blastocysts and progression through proamniotic cavity formation. Not required for preimplantation morphogenic process in blastocysts.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Nasopharyngeal Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3052","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3052"},{"label":"UniProt P15924","url":"https://www.uniprot.org/uniprotkb/P15924/entry"},{"label":"NCBI Gene 1832","url":"https://www.ncbi.nlm.nih.gov/gene/1832"},{"label":"Ensembl ENSG00000096696","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000096696"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["nasopharyngeal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct04988555"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DSP","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:3052","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3052","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15924","url":"https://www.uniprot.org/uniprotkb/P15924/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen DSP","url":"https://www.intogen.org/search?gene=DSP","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3052","ensembl":"ENSG00000096696","uniprot":"P15924","entrez":"1832","biology":"A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Critical for cell-cell adhesion in early stage blastocysts and progression through proamniotic cavity formation. Not required for preimplantation morphogenic process in blastocysts. Required for keratin filament anchoring at the desmosome junction and subsequent organisation of the keratin intermediate filament network within the cytoplasm. Required for anchoring of desmosomes to the microtubule architecture, via its interaction with NIN. Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with MAPRE1/EB1, thereby facilitating gap junction intracellular communication. Location: Cell projection, axon; Cell junction, desmosome; Cell membrane; Cytoplasm (UniProt). Locus 6p24.3 (HGNC).","whereFound":["Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/dsp/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"}],"trial":[{"id":"nct04988555","kind":"trial","name":"A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)","route":"/trials/nct04988555/"}]}}