{"entity":{"id":"duke-cryocompression-gyn","kind":"trial","name":"Duke cryocompression trial in gynaecological cancer","aka":["Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer"],"tldr":"Women having chemotherapy for gynaecological cancers wore a cooling-and-compression device. It reduced the numbness they reported, though a nerve test showed no difference.","summary":"The Duke trial enrolled 91 patients and analysed 69. Cryocompression lowered the odds of patient-reported sensory neuropathy (odds ratio 0.54, 95 per cent confidence interval 0.31 to 0.94), with no difference on monofilament testing. A second cohort is registered as NCT06139458.","status":"positive","asOf":"2026-11-04","links":[{"label":"ClinicalTrials.gov NCT04563130","url":"https://clinicaltrials.gov/study/NCT04563130"},{"label":"Anastasio et al., cryocompression during gynaecological chemotherapy, self-controlled randomised trial (Obstet Gynecol 2023)","url":"https://doi.org/10.1097/aog.0000000000005419"},{"label":"ClinicalTrials.gov NCT06139458","url":"https://clinicaltrials.gov/study/NCT06139458"}],"tags":["machines-wave3"],"related":[],"cancers":[],"sections":[],"technologies":["limb-cryocompression-devices"],"targets":[],"drugs":["paclitaxel","carboplatin"],"companies":[],"institutions":["duke-cancer-institute"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo machines inventory (openFDA, accessdata.fda.gov, ClinicalTrials.gov v2, Europe PMC, maker pages)","editedOn":"2026-11-04"},"nct":"NCT04563130","phase":"not-applicable","setting":"Patients with gynaecological cancer receiving taxane and platinum chemotherapy, with cryocompression on one side as a self-control","sponsor":"Duke University","result":"Patient-reported sensory neuropathy odds ratio 0.54 with cryocompression; no difference on monofilament testing.","started":"2021-01-11","startedType":"actual","yearReported":2023,"enrolled":91,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/duke-cryocompression-gyn/","neighbours":{"technology":[{"id":"limb-cryocompression-devices","kind":"technology","name":"Limb cryocompression devices for chemotherapy nerve damage (Paxman Neuropathy System, Hilotherm ChemoCare)","route":"/technologies/limb-cryocompression-devices/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"paclitaxel","kind":"drug","name":"Paclitaxel / nab-paclitaxel","route":"/drugs/paclitaxel/"}],"institution":[{"id":"duke-cancer-institute","kind":"institution","name":"Duke Cancer Institute","route":"/institutions/duke-cancer-institute/"}],"roadmap":[{"id":"chemo-chair-comfort-devices-roadmap","kind":"roadmap","name":"Comfort devices at the chemotherapy chair: scalp cooling, cold caps, limb cryocompression and infusion chairs","route":"/roadmaps/chemo-chair-comfort-devices-roadmap/"}]}}