{"entity":{"id":"dusp16","kind":"target","name":"DUSP16","aka":["dual specificity phosphatase 16","Dual specificity protein phosphatase 16","MKP-7","KIAA1700","MKP7"],"tldr":"DUSP16 (Dual specificity protein phosphatase 16) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.","summary":"Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Colorectal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17909","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17909"},{"label":"UniProt Q9BY84","url":"https://www.uniprot.org/uniprotkb/Q9BY84/entry"},{"label":"NCBI Gene 80824","url":"https://www.ncbi.nlm.nih.gov/gene/80824"},{"label":"Ensembl ENSG00000111266","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111266"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DUSP16","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:17909","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17909","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BY84","url":"https://www.uniprot.org/uniprotkb/Q9BY84/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen DUSP16","url":"https://www.intogen.org/search?gene=DUSP16","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:17909","ensembl":"ENSG00000111266","uniprot":"Q9BY84","entrez":"80824","biology":"Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. Location: Cytoplasm; Nucleus; Cytoplasmic vesicle (UniProt). Locus 12p13.2 (HGNC).","whereFound":["Colorectal cancer: IntOGen driver in 2 cohorts (COADREAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/dusp16/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}