{"entity":{"id":"e2f7","kind":"target","name":"E2F7","aka":["E2F transcription factor 7"],"tldr":"E2F7 is an unusual member of the E2F family that represses genes rather than activating them, helping cells pause after DNA damage.","summary":"UniProt describes E2F7 as an atypical E2F that mainly represses transcription, recognising the E2 site without a DP partner and participating in the DNA damage response. It is a cell-cycle gene whose transcript and protein can diverge, one of the examples of decoupled mRNA and protein in proteogenomic data.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:23820","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23820"},{"label":"UniProt Q96AV8","url":"https://www.uniprot.org/uniprotkb/Q96AV8/entry"}],"tags":["cansim-terms"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["p53-cell-cycle"],"terms":["co-amplification","cancer-ai-vocabulary","mrna-protein-concordance"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme."],"provenance":{"editedBy":"OnCo CanSim terms wave (HGNC REST, UniProt REST)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"symbol":"E2F7","role":["biomarker"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23820","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23820","note":"approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)"},{"label":"UniProt Q96AV8","url":"https://www.uniprot.org/uniprotkb/Q96AV8/entry","note":"protein name, function and tissue specificity text (REST API, 2026-09-24)"}],"specificitySources":[],"hgnc":"HGNC:23820","ensembl":"ENSG00000165891","uniprot":"Q96AV8","entrez":"144455","biology":"Atypical E2F transcription repressor that binds DNA independently of DP proteins and acts in angiogenesis, polyploidisation and the DNA damage response (UniProt Q96AV8).","whereFound":["Locus 12q21.2 (HGNC)."],"targetClass":"transcription","prevalence":[]},"route":"/targets/e2f7/","neighbours":{"pathway":[{"id":"p53-cell-cycle","kind":"pathway","name":"p53 / RB / cell-cycle checkpoint","route":"/pathways/p53-cell-cycle/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"co-amplification","kind":"term","name":"Co-amplification and the 17q12 HER2 amplicon","route":"/terms/co-amplification/"},{"id":"mrna-protein-concordance","kind":"term","name":"mRNA to protein concordance","route":"/terms/mrna-protein-concordance/"}]}}