{"entity":{"id":"ebf2","kind":"target","name":"EBF2","aka":["EBF transcription factor 2","Transcription factor COE2","FLJ11500","COE2"],"tldr":"EBF2 (Transcription factor COE2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.36, animal model 0.53, genetic association 0.64).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19090","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19090"},{"label":"UniProt Q9HAK2","url":"https://www.uniprot.org/uniprotkb/Q9HAK2/entry"},{"label":"NCBI Gene 64641","url":"https://www.ncbi.nlm.nih.gov/gene/64641"},{"label":"Ensembl ENSG00000221818","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000221818"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EBF2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:19090","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19090","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HAK2","url":"https://www.uniprot.org/uniprotkb/Q9HAK2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000221818","url":"https://platform.opentargets.org/target/ENSG00000221818/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:19090","ensembl":"ENSG00000221818","uniprot":"Q9HAK2","entrez":"64641","biology":"Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Location: Nucleus (UniProt). Locus 8p21.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/ebf2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}