{"entity":{"id":"eed","kind":"target","name":"EED","aka":["embryonic ectoderm development","Polycomb protein EED","WAIT-1"],"tldr":"EED (Polycomb protein EED) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and the evidence so far is association rather than a proven role.","summary":"Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognises 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.52, affected pathway 0.68, genetic association 0.19, somatic mutation 0.49). In OnCo, 1 product record names it (Rinzimetostat).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3188","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3188"},{"label":"UniProt O75530","url":"https://www.uniprot.org/uniprotkb/O75530/entry"},{"label":"NCBI Gene 8726","url":"https://www.ncbi.nlm.nih.gov/gene/8726"},{"label":"Ensembl ENSG00000074266","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000074266"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["rinzimetostat"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: 1 OnCo product record names it. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EED","role":["drug-target"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3188","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3188","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75530","url":"https://www.uniprot.org/uniprotkb/O75530/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000074266","url":"https://platform.opentargets.org/target/ENSG00000074266/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:3188","ensembl":"ENSG00000074266","uniprot":"O75530","entrez":"8726","biology":"Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognises 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. Location: Nucleus; Chromosome (UniProt). Locus 11q14.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/eed/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"drug":[{"id":"rinzimetostat","kind":"drug","name":"Rinzimetostat","route":"/drugs/rinzimetostat/"}]}}