{"entity":{"id":"eef2","kind":"target","name":"Elongation factor 2 (EEF2)","aka":[],"tldr":"EEF2 is the ribosome's motor for moving along messenger RNA; the CML drug omacetaxine stalls protein production by acting at this step.","summary":"Eukaryotic elongation factor 2 (EEF2) drives the translocation step of protein synthesis, moving the ribosome one codon along the messenger RNA after each amino acid is added. Omacetaxine mepesuccinate (homoharringtonine) binds the ribosome's A-site and blocks the first elongation steps, so short-lived proteins such as BCR-ABL1 and MCL1 fall quickly; the drug is approved for chronic myeloid leukaemia after two tyrosine kinase inhibitors.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/EEF2","links":[{"label":"UniProt P13639: EEF2","url":"https://www.uniprot.org/uniprotkb/P13639/entry"},{"label":"HGNC:3214 EEF2","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3214"},{"label":"ChEMBL target CHEMBL1795108","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL1795108"}],"tags":[],"related":[],"cancers":["cml"],"sections":[],"technologies":[],"targets":[],"drugs":["omacetaxine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"EEF2","biology":"A GTPase of the translation machinery; its activity is switched off by phosphorylation from eEF2 kinase under stress and starvation, one of the ways cells throttle protein synthesis.","whereFound":["All nucleated cells (housekeeping translation factor)","Highly active in rapidly dividing leukaemia and lymphoma cells"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/eef2/","neighbours":{"cancer":[{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"}],"drug":[{"id":"omacetaxine","kind":"drug","name":"Omacetaxine mepesuccinate","route":"/drugs/omacetaxine/"}]}}