{"entity":{"id":"eftud2","kind":"target","name":"EFTUD2","aka":["elongation factor Tu GTP binding domain containing 2","116 kDa U5 small nuclear ribonucleoprotein component","U5-116KD","Snrp116","Snu114","SNRNP116"],"tldr":"EFTUD2 (116 kDa U5 small nuclear ribonucleoprotein component) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma.","summary":"Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30858","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30858"},{"label":"UniProt Q15029","url":"https://www.uniprot.org/uniprotkb/Q15029/entry"},{"label":"NCBI Gene 9343","url":"https://www.ncbi.nlm.nih.gov/gene/9343"},{"label":"Ensembl ENSG00000108883","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108883"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["multiple-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EFTUD2","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30858","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30858","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15029","url":"https://www.uniprot.org/uniprotkb/Q15029/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen EFTUD2","url":"https://www.intogen.org/search?gene=EFTUD2","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30858","ensembl":"ENSG00000108883","uniprot":"Q15029","entrez":"9343","biology":"Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Location: Nucleus (UniProt). Locus 17q21.31 (HGNC).","whereFound":["Multiple myeloma: IntOGen driver in 1 cohort (PCM)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/eftud2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}]}}