{"entity":{"id":"ehbp1","kind":"target","name":"EHBP1","aka":["EH domain binding protein 1","EH domain-binding protein 1","KIAA0903","NACSIN"],"tldr":"EHBP1 (EH domain-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.18, genetic association 0.61, genetic literature 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29144","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29144"},{"label":"UniProt Q8NDI1","url":"https://www.uniprot.org/uniprotkb/Q8NDI1/entry"},{"label":"NCBI Gene 23301","url":"https://www.ncbi.nlm.nih.gov/gene/23301"},{"label":"Ensembl ENSG00000115504","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115504"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EHBP1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:29144","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29144","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8NDI1","url":"https://www.uniprot.org/uniprotkb/Q8NDI1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000115504","url":"https://platform.opentargets.org/target/ENSG00000115504/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:29144","ensembl":"ENSG00000115504","uniprot":"Q8NDI1","entrez":"23301","biology":"May play a role in actin reorganisation. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes. Location: Cytoplasm; Membrane; Endosome (UniProt). Locus 2p15 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/ehbp1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}