{"entity":{"id":"eif3e","kind":"target","name":"EIF3E","aka":["eukaryotic translation initiation factor 3 subunit E","Eukaryotic translation initiation factor 3 subunit E","eIF3-p48","INT6","EIF3S6"],"tldr":"EIF3E (Eukaryotic translation initiation factor 3 subunit E) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer and Lung cancer.","summary":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.17, somatic mutation 0.81). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Cervical Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3277","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3277"},{"label":"UniProt P60228","url":"https://www.uniprot.org/uniprotkb/P60228/entry"},{"label":"NCBI Gene 3646","url":"https://www.ncbi.nlm.nih.gov/gene/3646"},{"label":"Ensembl ENSG00000104408","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104408"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["cervical","breast-cancer","lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EIF3E","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:3277","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3277","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P60228","url":"https://www.uniprot.org/uniprotkb/P60228/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000104408","url":"https://platform.opentargets.org/target/ENSG00000104408/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: breast cancer 0.53, lung cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen EIF3E","url":"https://www.intogen.org/search?gene=EIF3E","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3277","ensembl":"ENSG00000104408","uniprot":"P60228","entrez":"3646","biology":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. Location: Cytoplasm; Nucleus, PML body (UniProt). Locus 8q23.1 (HGNC).","whereFound":["Cervical cancer: IntOGen driver in 1 cohort (CESC)","Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/eif3e/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"}]}}