{"entity":{"id":"elac2","kind":"target","name":"ELAC2","aka":["elaC ribonuclease Z 2","Zinc phosphodiesterase ELAC protein 2","FLJ10530","HPC2"],"tldr":"ELAC2 (Zinc phosphodiesterase ELAC protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.\n\nOpen Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.74, animal model 0.70, genetic association 0.84, genetic literature 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14198","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14198"},{"label":"UniProt Q9BQ52","url":"https://www.uniprot.org/uniprotkb/Q9BQ52/entry"},{"label":"NCBI Gene 60528","url":"https://www.ncbi.nlm.nih.gov/gene/60528"},{"label":"Ensembl ENSG00000006744","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000006744"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ELAC2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:14198","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14198","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BQ52","url":"https://www.uniprot.org/uniprotkb/Q9BQ52/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000006744","url":"https://platform.opentargets.org/target/ENSG00000006744/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: prostate cancer 0.74 (GraphQL API, CC0)"}],"hgnc":"HGNC:14198","ensembl":"ENSG00000006744","uniprot":"Q9BQ52","entrez":"60528","biology":"Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. Location: Mitochondrion; Mitochondrion matrix, mitochondrion nucleoid; Nucleus (UniProt). Locus 17p12 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.74 with prostate cancer (MONDO_0008315)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/elac2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}