{"entity":{"id":"elp4","kind":"target","name":"ELP4","aka":["elongator acetyltransferase complex subunit 4","Elongator complex protein 4","PAXNEB","C11orf19"],"tldr":"ELP4 (Elongator complex protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.","summary":"Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.37, animal model 0.57, genetic association 0.80).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1171","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1171"},{"label":"UniProt Q96EB1","url":"https://www.uniprot.org/uniprotkb/Q96EB1/entry"},{"label":"NCBI Gene 26610","url":"https://www.ncbi.nlm.nih.gov/gene/26610"},{"label":"Ensembl ENSG00000109911","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000109911"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ELP4","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1171","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1171","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96EB1","url":"https://www.uniprot.org/uniprotkb/Q96EB1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000109911","url":"https://platform.opentargets.org/target/ENSG00000109911/associations","note":"association with cancer (MONDO_0004992) 0.51; per-cancer scores at or above 0.5: renal cell carcinoma 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:1171","ensembl":"ENSG00000109911","uniprot":"Q96EB1","entrez":"26610","biology":"Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Location: Cytoplasm; Nucleus (UniProt). Locus 11p13 (HGNC).","whereFound":["Renal cell carcinoma: Open Targets association 0.50 with renal cell carcinoma (MONDO_0005086)"],"targetClass":"other","prevalence":[]},"route":"/targets/elp4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}