{"entity":{"id":"eortc-22922","kind":"trial","name":"EORTC 22922/10925","aka":[],"tldr":"EORTC 22922 showed that irradiating the internal mammary and supraclavicular nodes reduces breast cancer recurrence and death, with a small effect on overall survival, and made regional nodal irradiation standard for node-positive disease.","summary":"EORTC 22922/10925 randomised 4,004 women with node-positive or medially located early breast cancer to whole-breast or chest wall radiotherapy with or without irradiation of the internal mammary and medial supraclavicular nodes. Ten-year overall survival was 82.3 percent with nodal irradiation and 80.7 percent without (hazard ratio 0.87, borderline), with fewer distant recurrences and breast cancer deaths (Poortmans and colleagues, New England Journal of Medicine 2015); 15-year results confirmed lower breast cancer mortality without an overall survival difference.","status":"positive","asOf":"2026-09-17","links":[{"label":"ClinicalTrials.gov NCT00002851","url":"https://clinicaltrials.gov/study/NCT00002851"},{"label":"NEJM 2015","url":"https://doi.org/10.1056/NEJMoa1415369"}],"tags":["radiation-wave4"],"related":[],"cancers":["breast-hr-positive","breast-her2-positive","tnbc"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["planning-target-volume"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT00002851","phase":"3","setting":"Early breast cancer with involved axillary nodes or a central or medial tumour: regional nodal irradiation (internal mammary and medial supraclavicular) added to breast or chest wall radiotherapy, versus none","sponsor":"EORTC","result":"10-year overall survival 82.3% vs 80.7% (hazard ratio 0.87); fewer distant recurrences and breast cancer deaths.","yearReported":2015,"enrolled":4004,"outcomes":[{"endpoint":"Overall survival at 10 years","primary":true,"unit":"%","arms":[{"name":"Regional nodal irradiation","n":2002,"value":82.3},{"name":"No nodal irradiation","n":2002,"value":80.7}]}]},"route":"/trials/eortc-22922/","neighbours":{"cancer":[{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"planning-target-volume","kind":"term","name":"GTV, CTV and PTV (target volumes)","route":"/terms/planning-target-volume/"}]}}