{"entity":{"id":"eortc-26951","kind":"trial","name":"EORTC 26951","aka":[],"tldr":"EORTC 26951, the European twin of RTOG 9402, confirmed that PCV chemotherapy after radiotherapy greatly lengthens survival in 1p/19q co-deleted oligodendrogliomas.","summary":"EORTC 26951 randomised 368 patients with anaplastic oligodendroglioma or oligoastrocytoma to 59.4 Gy radiotherapy with or without six cycles of adjuvant PCV. With a median follow-up of nearly 12 years, overall survival improved with PCV (42.3 versus 30.6 months overall); in 1p/19q co-deleted tumours median survival was not reached with PCV versus 112 months with radiotherapy alone (van den Bent and colleagues, Journal of Clinical Oncology 2013).","status":"positive","asOf":"2026-09-17","links":[{"label":"JCO 2013","url":"https://doi.org/10.1200/JCO.2012.43.2229"}],"tags":["radiation-wave4"],"related":[],"cancers":["glioblastoma","brain-tumours"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":["lomustine","vincristine","procarbazine"],"companies":[],"institutions":[],"pathways":[],"terms":["chemoradiation"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"phase":"3","setting":"Anaplastic oligodendroglial tumours: radiotherapy followed by six cycles of PCV chemotherapy versus radiotherapy alone","sponsor":"EORTC","result":"Median overall survival 42.3 vs 30.6 months overall; in 1p/19q co-deleted tumours not reached vs 112 months.","yearReported":2013,"enrolled":368,"outcomes":[]},"route":"/trials/eortc-26951/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"lomustine","kind":"drug","name":"Lomustine (CCNU)","route":"/drugs/lomustine/"},{"id":"procarbazine","kind":"drug","name":"Procarbazine","route":"/drugs/procarbazine/"},{"id":"vincristine","kind":"drug","name":"Vincristine","route":"/drugs/vincristine/"}],"term":[{"id":"chemoradiation","kind":"term","name":"Chemoradiation (chemoradiotherapy, CRT)","route":"/terms/chemoradiation/"}]}}