{"entity":{"id":"eosinophilic-solid-cystic-renal-cell-carcinoma","kind":"cancer","name":"Eosinophilic solid and cystic renal cell carcinoma","aka":["ESC RCC","Eosinophilic, solid and cystic renal cell carcinoma","TSC-associated eosinophilic renal cell carcinoma (syndromic form)"],"tldr":"Eosinophilic solid and cystic renal cell carcinoma is a recently named kidney cancer, almost always in women, made of pink cells in solid areas and cysts. It was first seen in people with tuberous sclerosis and then found on its own, it is nearly always confined to the kidney, and surgery cures it in almost every reported case.","summary":"The 2022 WHO classification introduced eosinophilic solid and cystic renal cell carcinoma as a new morphologically defined type (Moch 2022). It was first described in patients with tuberous sclerosis complex; a search for a sporadic counterpart found 16 morphologically identical tumours, all in women without clinical tuberous sclerosis, median age 57, with solid and macrocystic growth, voluminous eosinophilic cytoplasm with granular stippling, hobnail cyst lining, nuclear PAX8, a CK20-positive and CK7-negative phenotype and no CD117; 13 of 16 were stage pT1 (Am J Surg Pathol 2016). In 19 further cases, all women, median age 55 and median size 31 mm, CK20 was positive in 74 percent, 89 percent were pT1, and 15 of 16 with follow-up were alive without disease (Am J Surg Pathol 2017). Sporadic cases carry somatic TSC1 or TSC2 mutations, the same pathway as the syndromic form.\n\nHow it differs from its parent: a female-only series, tuberous sclerosis biology (mTOR pathway), CK20 positivity and an indolent course with rare metastasis; it is distinguished from oncocytoma and chromophobe carcinoma by the cysts, the stippled cytoplasm and CK20.\n\nHow common: no registry share.\n\nTreatment: partial nephrectomy; the mTOR inhibitor everolimus, approved for tuberous sclerosis-associated tumours, is the rational choice for the rare metastatic case, without trial evidence in this type.","asOf":"2026-09-24","wikipedia":"https://en.wikipedia.org/wiki/Renal_cell_carcinoma","links":[{"label":"Moch 2022, European Urology: the 2022 WHO classification of urinary and male genital tumours, part A (renal, penile, testicular)","url":"https://doi.org/10.1016/j.eururo.2022.06.016"},{"label":"Am J Surg Pathol 2016: eosinophilic, solid and cystic renal cell carcinoma, 16 sporadic cases in women","url":"https://doi.org/10.1097/pas.0000000000000508"},{"label":"Am J Surg Pathol 2017: eosinophilic solid and cystic RCC, further characterisation of 19 cases","url":"https://doi.org/10.1097/pas.0000000000000838"}],"tags":["subtype-page","wave4","kidney","rare"],"related":["rcc","chromophobe-rcc","sdh-deficient-renal-cell-carcinoma","mucinous-tubular-spindle-cell-carcinoma"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["everolimus"],"companies":[],"institutions":[],"pathways":[],"terms":["nephrectomy"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"group":"genitourinary","burden":"Rare: 16 sporadic cases, all in women, median age 57 (Am J Surg Pathol 2016), and 19 further cases, all women, median age 55 (Am J Surg Pathol 2017). No registry share exists for a type named in 2022.","subtypes":[],"biomarkers":["CK20 positive, CK7 negative, CD117 negative","Somatic or germline TSC1 or TSC2 mutation","Solid and cystic architecture with stippled eosinophilic cytoplasm","Stage (nearly always pT1)"],"standardOfCare":[{"setting":"All stages","approach":"Partial nephrectomy; everolimus is the rational choice for rare metastatic disease on the tuberous sclerosis biology, without trial evidence.","refs":["rcc","nephrectomy","everolimus"]}],"stateOfArt":[],"history":[],"pipeline":[],"openProblems":[],"parent":"rcc"},"route":"/cancers/eosinophilic-solid-cystic-renal-cell-carcinoma/","neighbours":{"cancer":[{"id":"chromophobe-rcc","kind":"cancer","name":"Chromophobe renal cell carcinoma","route":"/cancers/chromophobe-rcc/"},{"id":"mucinous-tubular-spindle-cell-carcinoma","kind":"cancer","name":"Mucinous tubular and spindle cell carcinoma of the kidney","route":"/cancers/mucinous-tubular-spindle-cell-carcinoma/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"sdh-deficient-renal-cell-carcinoma","kind":"cancer","name":"Succinate dehydrogenase-deficient renal cell carcinoma","route":"/cancers/sdh-deficient-renal-cell-carcinoma/"}],"drug":[{"id":"everolimus","kind":"drug","name":"Everolimus","route":"/drugs/everolimus/"}],"term":[{"id":"nephrectomy","kind":"term","name":"Nephrectomy","route":"/terms/nephrectomy/"}]}}