{"entity":{"id":"epha10","kind":"target","name":"EPHA10","aka":["EPH receptor A10","Ephrin type-A receptor 10","FLJ16103","FLJ33655"],"tldr":"EPHA10 (Ephrin type-A receptor 10) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.","summary":"Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.03, clinical 0.93).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19987","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19987"},{"label":"UniProt Q5JZY3","url":"https://www.uniprot.org/uniprotkb/Q5JZY3/entry"},{"label":"NCBI Gene 284656","url":"https://www.ncbi.nlm.nih.gov/gene/284656"},{"label":"Ensembl ENSG00000183317","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183317"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["thyroid","neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EPHA10","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:19987","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19987","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5JZY3","url":"https://www.uniprot.org/uniprotkb/Q5JZY3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000183317","url":"https://platform.opentargets.org/target/ENSG00000183317/associations","note":"association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: thyroid cancer 0.56, neuroendocrine neoplasm 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:19987","ensembl":"ENSG00000183317","uniprot":"Q5JZY3","entrez":"284656","biology":"Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Location: Cell membrane; Secreted (UniProt). Locus 1p34.3 (HGNC).","whereFound":["Thyroid cancer: Open Targets association 0.56 with thyroid cancer (MONDO_0002108)","Neuroendocrine tumours: Open Targets association 0.54 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"other","prevalence":[]},"route":"/targets/epha10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}