{"entity":{"id":"epha2","kind":"target","name":"EphA2 receptor","aka":[],"tldr":"EphA2 is a cell-guidance receptor that many solid tumours overexpress; dasatinib and regorafenib block it among their many kinase targets, and it is being tested as an antibody-drug conjugate and CAR-T target.","summary":"Ephrin type-A receptor 2 helps cells read their neighbours' positions during development and is overexpressed in glioblastoma, ovarian, breast, lung and pancreatic cancers, where ligand-independent signalling promotes invasion. Dasatinib and regorafenib inhibit it as secondary targets. Antibody-drug conjugates and CAR-T cells against EphA2 have reached early trials, notably in glioblastoma.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/EPH_receptor_A2","links":[{"label":"UniProt P29317: EPHA2","url":"https://www.uniprot.org/uniprotkb/P29317/entry"},{"label":"HGNC:3386 EPHA2","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3386"},{"label":"ChEMBL target CHEMBL2068","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2068"}],"tags":[],"related":[],"cancers":["glioblastoma","ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":["dasatinib","regorafenib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"EPHA2","biology":"A receptor tyrosine kinase for ephrin-A ligands; ligand binding suppresses growth signalling, while unliganded EphA2 phosphorylated by AKT drives motility.","whereFound":["Glioblastoma, ovarian, breast, lung and pancreatic cancers (overexpressed)","Low in normal adult epithelium"],"targetClass":"kinase","prevalence":[]},"route":"/targets/epha2/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"drug":[{"id":"dasatinib","kind":"drug","name":"Dasatinib","route":"/drugs/dasatinib/"},{"id":"regorafenib","kind":"drug","name":"Regorafenib","route":"/drugs/regorafenib/"}]}}