{"entity":{"id":"eps15","kind":"target","name":"EPS15","aka":["epidermal growth factor receptor pathway substrate 15","Epidermal growth factor receptor substrate 15","AF-1P","MLLT5"],"tldr":"EPS15 (Epidermal growth factor receptor substrate 15) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Non-Hodgkin lymphoma and 2 more.","summary":"Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalisation of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.35, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3419","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3419"},{"label":"UniProt P42566","url":"https://www.uniprot.org/uniprotkb/P42566/entry"},{"label":"NCBI Gene 2060","url":"https://www.ncbi.nlm.nih.gov/gene/2060"},{"label":"Ensembl ENSG00000085832","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085832"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["prostate","breast-cancer","non-hodgkin-lymphoma","skin-cancer","leukaemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EPS15","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:3419","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3419","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P42566","url":"https://www.uniprot.org/uniprotkb/P42566/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000085832","url":"https://platform.opentargets.org/target/ENSG00000085832/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.52, skin cancer 0.51, breast cancer 0.53, leukaemia 0.51 (GraphQL API, CC0)"},{"label":"IntOGen EPS15","url":"https://www.intogen.org/search?gene=EPS15","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3419","ensembl":"ENSG00000085832","uniprot":"P42566","entrez":"2060","biology":"Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalisation of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Location: Cytoplasm; Cell membrane; Membrane, clathrin-coated pit; Early endosome membrane (UniProt). Locus 1p32.3 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/eps15/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}