{"entity":{"id":"erapa","kind":"drug","name":"eRapa","aka":["encapsulated rapamycin"],"tldr":"eRapa is a new form of the drug rapamycin from Biodexa Pharmaceuticals, designed to be absorbed more reliably. It is in a large trial in an inherited condition that causes many bowel polyps, and a smaller trial in early bladder cancer.","summary":"eRapa, licensed by Biodexa Pharmaceuticals from Emtora Biosciences in April 2024, is in a double-blind, placebo-controlled registrational phase 3 study in 168 patients with familial adenomatous polyposis, randomised 2:1, at about 30 sites in the United States and Europe; the first patients enrolled in August 2025 and recruitment passed the half-way point in August 2026. An investigator-initiated phase 2 study in non-muscle invasive bladder cancer is being conducted by the University of Texas, San Antonio. Biodexa announced FDA fast track designation for eRapa on 10 February 2025.","status":"phase-3","asOf":"2026-11-04","links":[{"label":"SEC: Biodexa Pharmaceuticals Form F-1, September 2026","url":"https://www.sec.gov/Archives/edgar/data/1643918/000121465926011934/y917262f1.htm"}],"tags":["pipeline"],"related":["sirolimus"],"cancers":[],"sections":[],"technologies":[],"targets":["mtor"],"drugs":[],"companies":["biodexa-pharmaceuticals"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors","editedOn":"2026-11-04"},"modality":"mTOR inhibitor (encapsulated rapamycin formulation)","mechanism":"A formulation of rapamycin, an mTOR inhibitor, using nanotechnology and pH-sensitive polymers to improve its bioavailability and reduce variable pharmacokinetics and toxicity, as described by Biodexa Pharmaceuticals.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/erapa/","neighbours":{"drug":[{"id":"sirolimus","kind":"drug","name":"Sirolimus","route":"/drugs/sirolimus/"}],"target":[{"id":"mtor","kind":"target","name":"mTOR","route":"/targets/mtor/"}],"company":[{"id":"biodexa-pharmaceuticals","kind":"company","name":"Biodexa Pharmaceuticals","route":"/companies/biodexa-pharmaceuticals/"}]}}