{"entity":{"id":"erbin","kind":"target","name":"ERBIN","aka":["erbb2 interacting protein","Erbin","LAP2","ERBB2IP"],"tldr":"ERBIN (Erbin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.97, genetic association 0.04, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:15842","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15842"},{"label":"UniProt Q96RT1","url":"https://www.uniprot.org/uniprotkb/Q96RT1/entry"},{"label":"NCBI Gene 55914","url":"https://www.ncbi.nlm.nih.gov/gene/55914"},{"label":"Ensembl ENSG00000112851","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112851"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ERBIN","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:15842","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15842","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96RT1","url":"https://www.uniprot.org/uniprotkb/Q96RT1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000112851","url":"https://platform.opentargets.org/target/ENSG00000112851/associations","note":"association with cancer (MONDO_0004992) 0.64;  (GraphQL API, CC0)"}],"hgnc":"HGNC:15842","ensembl":"ENSG00000112851","uniprot":"Q96RT1","entrez":"55914","biology":"Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilise this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signalling and pro-inflammatory cytokine secretion. Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes. Location: Cell junction, hemidesmosome; Nucleus membrane; Basolateral cell membrane; Cytoplasm (UniProt). Locus 5q12.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/erbin/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}