{"entity":{"id":"ercc1","kind":"target","name":"ERCC1","aka":["ERCC excision repair 1, endonuclease non-catalytic subunit","DNA excision repair protein ERCC-1","RAD10"],"tldr":"ERCC1 (DNA excision repair protein ERCC-1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Mesothelioma, Ovarian cancer and 1 more.","summary":"Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure.\n\nCIViC holds 11 clinical evidence items and 0 assertions across 3 variants, naming Gemcitabine, Cisplatin, Platinum Compound and Paclitaxel and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3433","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3433"},{"label":"UniProt P07992","url":"https://www.uniprot.org/uniprotkb/P07992/entry"},{"label":"NCBI Gene 2067","url":"https://www.ncbi.nlm.nih.gov/gene/2067"},{"label":"Ensembl ENSG00000012061","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000012061"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["urothelial","mesothelioma","ovarian","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 6 therapies; CIViC holds 11 clinical evidence items on its variants; UniProt keyword \"DNA repair\". Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ERCC1","role":["drug-target","biomarker","dna-repair"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3433","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3433","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P07992","url":"https://www.uniprot.org/uniprotkb/P07992/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ERCC1","url":"https://civicdb.org/features/1735","note":"11 evidence items, 0 assertions, 3 variants; diseases: Lung Non-small Cell Carcinoma, Bladder Carcinoma, Malignant Pleural Mesothelioma, Epithelial Ovarian Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:3433","ensembl":"ENSG00000012061","uniprot":"P07992","entrez":"2067","biology":"Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. Not functional in the nucleotide excision repair pathway. Not functional in the nucleotide excision repair pathway. Location: Nucleus; Cytoplasm (UniProt). Locus 19q13.32 (HGNC).","whereFound":["Bladder & urothelial cancer: CIViC evidence names this disease","Mesothelioma: CIViC evidence names this disease","Ovarian cancer: CIViC evidence names this disease","Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/ercc1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}