{"entity":{"id":"erg","kind":"target","name":"ERG","aka":["ETS transcription factor ERG","Transcriptional regulator ERG","erg-3","p55"],"tldr":"ERG (Transcriptional regulator ERG) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Prostate cancer, Non-Hodgkin lymphoma and 4 more.","summary":"Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes genetic literature 0.61, literature 1.00, genetic association 0.03, somatic mutation 0.83, animal model 0.57). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Angiosarcoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3446","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3446"},{"label":"UniProt P11308","url":"https://www.uniprot.org/uniprotkb/P11308/entry"},{"label":"NCBI Gene 2078","url":"https://www.ncbi.nlm.nih.gov/gene/2078"},{"label":"Ensembl ENSG00000157554","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000157554"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["sarcoma","prostate","non-hodgkin-lymphoma","leukaemia","neuroendocrine","all-leukemia","angiosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ERG","role":["oncogene-driver","biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3446","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3446","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P11308","url":"https://www.uniprot.org/uniprotkb/P11308/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ERG","url":"https://civicdb.org/features/71","note":"1 evidence items, 0 assertions, 1 variants; diseases: B-lymphoblastic Leukaemia/lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000157554","url":"https://platform.opentargets.org/target/ENSG00000157554/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: prostate cancer 0.58, sarcoma 0.67, neuroendocrine neoplasm 0.52, acute lymphoblastic leukaemia 0.54, non-Hodgkin lymphoma 0.56, leukaemia 0.56 (GraphQL API, CC0)"},{"label":"IntOGen ERG","url":"https://www.intogen.org/search?gene=ERG","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3446","ensembl":"ENSG00000157554","uniprot":"P11308","entrez":"2078","biology":"Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. Location: Nucleus; Cytoplasm (UniProt). Locus 21q22.2 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.67 with sarcoma (MONDO_0005089)","Prostate cancer: Open Targets association 0.58 with prostate cancer (MONDO_0008315)","Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)","Leukaemia: Open Targets association 0.56 with leukaemia (MONDO_0005059)","Neuroendocrine tumours: Open Targets association 0.52 with neuroendocrine neoplasm (MONDO_0019496)","Acute lymphoblastic leukaemia: Open Targets association 0.54 with acute lymphoblastic leukaemia (MONDO_0004967); CIViC evidence names this disease"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/erg/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"angiosarcoma","kind":"cancer","name":"Angiosarcoma","route":"/cancers/angiosarcoma/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}