{"entity":{"id":"erlin2","kind":"target","name":"ERLIN2","aka":["ER lipid raft associated 2","Erlin-2","NET32","C8orf2","SPFH2","SPG18"],"tldr":"ERLIN2 (Erlin-2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signalling pathway.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.95, genetic association 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1356","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1356"},{"label":"UniProt O94905","url":"https://www.uniprot.org/uniprotkb/O94905/entry"},{"label":"NCBI Gene 11160","url":"https://www.ncbi.nlm.nih.gov/gene/11160"},{"label":"Ensembl ENSG00000147475","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147475"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ERLIN2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1356","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1356","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O94905","url":"https://www.uniprot.org/uniprotkb/O94905/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000147475","url":"https://platform.opentargets.org/target/ENSG00000147475/associations","note":"association with cancer (MONDO_0004992) 0.64;  (GraphQL API, CC0)"}],"hgnc":"HGNC:1356","ensembl":"ENSG00000147475","uniprot":"O94905","entrez":"11160","biology":"Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signalling pathway. May promote ER retention of the SCAP-SREBF complex. Location: Endoplasmic reticulum membrane (UniProt). Locus 8p11.23 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/erlin2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}