{"entity":{"id":"eryaspase","kind":"drug","name":"Eryaspase","aka":["GRASPA","L-asparaginase encapsulated in red blood cells"],"tldr":"Eryaspase packed a leukaemia enzyme into red blood cells to starve pancreatic cancer of an amino acid; the phase 3 TRYbeCA-1 trial missed its survival goal.","summary":"Erytech Pharma, now part of Phaxiam, built eryaspase for tumours that cannot make their own asparagine. A randomised phase 2 in second-line pancreatic cancer had shown longer survival, which led to the phase 3 TRYbeCA-1 trial of eryaspase with chemotherapy against chemotherapy alone in the second line.\n\nTRYbeCA-1 reported in 2021: overall survival was not significantly improved, and the pancreatic programme ended.","status":"negative","asOf":"2026-09-17","links":[{"label":"ClinicalTrials.gov NCT03665441","url":"https://clinicaltrials.gov/study/NCT03665441"}],"tags":[],"related":[],"cancers":["pancreatic"],"sections":[],"technologies":["cytotoxic-chemotherapy"],"targets":[],"drugs":[],"companies":["phaxiam"],"institutions":[],"pathways":[],"terms":[],"trials":["trybeca-1"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"code":"GRASPA","modality":"L-asparaginase encapsulated in donor red blood cells","mechanism":"Depletes circulating asparagine, an amino acid that pancreatic tumours with low asparagine synthetase cannot make, while the red-cell shell protects the enzyme and reduces toxicity.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/eryaspase/","neighbours":{"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"}],"company":[{"id":"phaxiam","kind":"company","name":"Phaxiam Therapeutics (formerly ERYtech Pharma)","route":"/companies/phaxiam/"}],"trial":[{"id":"trybeca-1","kind":"trial","name":"TRYbeCA-1","route":"/trials/trybeca-1/"}]}}