{"entity":{"id":"etnk1","kind":"target","name":"ETNK1","aka":["ethanolamine kinase 1","Ethanolamine kinase 1","EKI1"],"tldr":"ETNK1 (Ethanolamine kinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer and Myeloproliferative neoplasms.","summary":"Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.18, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24649","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24649"},{"label":"UniProt Q9HBU6","url":"https://www.uniprot.org/uniprotkb/Q9HBU6/entry"},{"label":"NCBI Gene 55500","url":"https://www.ncbi.nlm.nih.gov/gene/55500"},{"label":"Ensembl ENSG00000139163","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139163"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","breast-cancer","myeloproliferative-neoplasms"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ETNK1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:24649","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24649","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HBU6","url":"https://www.uniprot.org/uniprotkb/Q9HBU6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000139163","url":"https://platform.opentargets.org/target/ENSG00000139163/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: myeloproliferative neoplasm 0.51, breast cancer 0.51, leukaemia 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:24649","ensembl":"ENSG00000139163","uniprot":"Q9HBU6","entrez":"55500","biology":"Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. Location: Cytoplasm (UniProt). Locus 12p12.1 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)","Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)","Myeloproliferative neoplasms: Open Targets association 0.51 with myeloproliferative neoplasm (MONDO_0020076)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/etnk1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"}]}}