{"entity":{"id":"ets2","kind":"target","name":"ETS2","aka":["ETS proto-oncogene 2, transcription factor"],"tldr":"ETS2 (ETS proto-oncogene 2, transcription factor) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel and Cisplatin.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3489"},{"label":"UniProt P15036","url":"https://www.uniprot.org/uniprotkb/P15036/entry"},{"label":"NCBI Gene 2114","url":"https://www.ncbi.nlm.nih.gov/gene/2114"},{"label":"Ensembl ENSG00000157557","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000157557"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ETS2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3489","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15036","url":"https://www.uniprot.org/uniprotkb/P15036/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ETS2","url":"https://civicdb.org/features/1763","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:3489","ensembl":"ENSG00000157557","uniprot":"P15036","entrez":"2114","biology":"Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. Location: Nucleus (UniProt). Locus 21q22.2 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ets2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}