{"entity":{"id":"etv5","kind":"target","name":"ETV5","aka":["ETS variant transcription factor 5","ETS translocation variant 5"],"tldr":"ETV5 (ETS translocation variant 5) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Neuroendocrine tumours and 4 more.","summary":"Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Trametinib. Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.20, somatic mutation 0.85). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3494","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3494"},{"label":"UniProt P41161","url":"https://www.uniprot.org/uniprotkb/P41161/entry"},{"label":"NCBI Gene 2119","url":"https://www.ncbi.nlm.nih.gov/gene/2119"},{"label":"Ensembl ENSG00000244405","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000244405"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["lung-cancer","pancreatic","neuroendocrine","skin-cancer","breast-cancer","colorectal","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ETV5","role":["drug-target","oncogene-driver","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3494","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3494","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P41161","url":"https://www.uniprot.org/uniprotkb/P41161/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ETV5","url":"https://civicdb.org/features/1768","note":"2 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer, Pancreatic Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000244405","url":"https://platform.opentargets.org/target/ENSG00000244405/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.51, neuroendocrine neoplasm 0.56, skin cancer 0.52, breast cancer 0.52 (GraphQL API, CC0)"},{"label":"IntOGen ETV5","url":"https://www.intogen.org/search?gene=ETV5","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3494","ensembl":"ENSG00000244405","uniprot":"P41161","entrez":"2119","biology":"Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. Location: Nucleus (UniProt). Locus 3q27.2 (HGNC).","whereFound":["Lung cancer: CIViC evidence names this disease","Pancreatic ductal adenocarcinoma: CIViC evidence names this disease","Neuroendocrine tumours: Open Targets association 0.56 with neuroendocrine neoplasm (MONDO_0019496)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/etv5/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}