{"entity":{"id":"etx-197","kind":"drug","name":"ETX-197","aka":[],"tldr":"ETX-197 is an experimental small molecule from Ensem Therapeutics, in preclinical development for solid tumours with cyclin E amplification.","summary":"ETX-197 is a small molecule (oral) from Ensem Therapeutics. An oral CDK2 inhibitor, which the company believes could treat tumours with cyclin E amplification and cancers that have become resistant to standard treatment through CDK2 dysregulation. Its furthest stage is preclinical development, for solid tumours with cyclin E amplification. No clinical trial naming it is registered on ClinicalTrials.gov. No ClinicalTrials.gov record for ETX-197. The pipeline chart's stage is graphical only (bar not readable as text); 'preclinical' follows OnCo's text and the absence of a registered trial, not a stated source. It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"Ensem Therapeutics: ensemtx.com","url":"https://ensemtx.com/science/pipeline/"}],"tags":["pipeline"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["cdk2"],"drugs":[],"companies":["ensem-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"ETX-197","modality":"Small molecule (oral)","mechanism":"An oral CDK2 inhibitor, which the company believes could treat tumours with cyclin E amplification and cancers that have become resistant to standard treatment through CDK2 dysregulation.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/etx-197/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"cdk2","kind":"target","name":"CDK2","route":"/targets/cdk2/"}],"company":[{"id":"ensem-therapeutics","kind":"company","name":"Ensem Therapeutics","route":"/companies/ensem-therapeutics/"}]}}