{"entity":{"id":"ext2","kind":"target","name":"EXT2","aka":["exostosin glycosyltransferase 2","Exostosin-2"],"tldr":"EXT2 (Exostosin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Ovarian cancer, Skin cancer and Breast cancer.","summary":"Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyses the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity.\n\nOpen Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.84, affected pathway 0.25, genetic association 0.64, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3513","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3513"},{"label":"UniProt Q93063","url":"https://www.uniprot.org/uniprotkb/Q93063/entry"},{"label":"NCBI Gene 2132","url":"https://www.ncbi.nlm.nih.gov/gene/2132"},{"label":"Ensembl ENSG00000151348","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000151348"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["ovarian","skin-cancer","breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EXT2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:3513","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3513","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q93063","url":"https://www.uniprot.org/uniprotkb/Q93063/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000151348","url":"https://platform.opentargets.org/target/ENSG00000151348/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: ovarian cancer 0.57, skin cancer 0.51, breast cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:3513","ensembl":"ENSG00000151348","uniprot":"Q93063","entrez":"2132","biology":"Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyses the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signalling. Location: Golgi apparatus membrane; Golgi apparatus, cis-Golgi network membrane; Endoplasmic reticulum membrane; Secreted (UniProt). Locus 11p11.2 (HGNC).","whereFound":["Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.50 with breast cancer (MONDO_0007254)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ext2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}