{"entity":{"id":"ezr","kind":"target","name":"EZR","aka":["ezrin","Ezrin","VIL2"],"tldr":"EZR (Ezrin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Lung cancer.","summary":"Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.99, animal model 0.50, genetic association 0.00, somatic mutation 0.91).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12691","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12691"},{"label":"UniProt P15311","url":"https://www.uniprot.org/uniprotkb/P15311/entry"},{"label":"NCBI Gene 7430","url":"https://www.ncbi.nlm.nih.gov/gene/7430"},{"label":"Ensembl ENSG00000092820","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000092820"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EZR","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12691","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12691","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15311","url":"https://www.uniprot.org/uniprotkb/P15311/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000092820","url":"https://platform.opentargets.org/target/ENSG00000092820/associations","note":"association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: lung cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:12691","ensembl":"ENSG00000092820","uniprot":"P15311","entrez":"7430","biology":"Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. Location: Apical cell membrane; Cell projection; Cell projection, microvillus membrane; Cell projection, ruffle membrane (UniProt). Locus 6q25.3 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)"],"targetClass":"other","prevalence":[]},"route":"/targets/ezr/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"}]}}