{"entity":{"id":"fam114a2","kind":"target","name":"FAM114A2","aka":["family with sequence similarity 114 member A2","133K02","C5orf3"],"tldr":"FAM114A2 (family with sequence similarity 114 member A2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"UniProt has no function text for Q9NRY5; HGNC names it \"family with sequence similarity 114 member A2\".\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.12, affected pathway 0.89, genetic association 0.03).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1333","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1333"},{"label":"UniProt Q9NRY5","url":"https://www.uniprot.org/uniprotkb/Q9NRY5/entry"},{"label":"NCBI Gene 10827","url":"https://www.ncbi.nlm.nih.gov/gene/10827"},{"label":"Ensembl ENSG00000055147","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000055147"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FAM114A2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:1333","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1333","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NRY5","url":"https://www.uniprot.org/uniprotkb/Q9NRY5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000055147","url":"https://platform.opentargets.org/target/ENSG00000055147/associations","note":"association with cancer (MONDO_0004992) 0.55;  (GraphQL API, CC0)"}],"hgnc":"HGNC:1333","ensembl":"ENSG00000055147","uniprot":"Q9NRY5","entrez":"10827","biology":"UniProt has no function text for Q9NRY5; HGNC names it \"family with sequence similarity 114 member A2\". Locus 5q33.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fam114a2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}