{"entity":{"id":"fam135b","kind":"target","name":"FAM135B","aka":["family with sequence similarity 135 member B","C8ORFK32"],"tldr":"FAM135B (family with sequence similarity 135 member B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Endometrial cancer and 4 more.","summary":"UniProt has no function text for Q49AJ0; HGNC names it \"family with sequence similarity 135 member B\".\n\nIntOGen calls it a driver in 9 cohorts (3 activating, 6 loss-of-function), covering Head and Neck Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma, Pancreatic Adenocarcinoma, Endometrial Carcinoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour, Well-Differentiated Thyroid Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:28029","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28029"},{"label":"UniProt Q49AJ0","url":"https://www.uniprot.org/uniprotkb/Q49AJ0/entry"},{"label":"NCBI Gene 51059","url":"https://www.ncbi.nlm.nih.gov/gene/51059"},{"label":"Ensembl ENSG00000147724","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147724"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["head-and-neck","pancreatic","endometrial","thyroid","nsclc","uterine-carcinosarcoma","papillary-thyroid-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 6 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FAM135B","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:28029","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28029","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q49AJ0","url":"https://www.uniprot.org/uniprotkb/Q49AJ0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen FAM135B","url":"https://www.intogen.org/search?gene=FAM135B","note":"driver in 9 cohorts (Act 3, LoF 6); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:28029","ensembl":"ENSG00000147724","uniprot":"Q49AJ0","entrez":"51059","biology":"UniProt has no function text for Q49AJ0; HGNC names it \"family with sequence similarity 135 member B\". Locus 8q24.23 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: IntOGen driver in 2 cohorts (HNSC)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)","Endometrial cancer: IntOGen driver in 1 cohort (UCEC)","Thyroid cancer: IntOGen driver in 1 cohort (WDTC)","Non-small-cell lung cancer: IntOGen driver in 3 cohorts (LUSC)","Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/fam135b/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"papillary-thyroid-cancer","kind":"cancer","name":"Papillary thyroid cancer","route":"/cancers/papillary-thyroid-cancer/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"},{"id":"uterine-carcinosarcoma","kind":"cancer","name":"Uterine carcinosarcoma","route":"/cancers/uterine-carcinosarcoma/"}]}}